Employing institution: Noguchi Memorial Institute for Medical Research, University of Ghana

Host institution: University of Cambridge, UK

Project title: Building capacity in computational biology for exploring the clinical relevance of zoonotic TB and non-tuberculous mycobacteria towards future control tools development and drug resistance monitoring.

Dr Asare’s PhD research identified hotspots for recent tuberculosis (TB) transmission which provided evidence-based data to the national tuberculosis control programme for performing targeted screening of population at risk. Currently, he is a research fellow at the Noguchi Memorial Institute for Medical Research, where his research focuses on understanding the transmission dynamics of mycobacteria related diseases, he also provides postgraduate supervision, offers teaching/training, and supports laboratory quality management systems.

AREF Fellowship:

To date, there is limited knowledge about Mycobacterium bovis transmission in Ghana. The work of Dr Asare and colleagues has demonstrated that M. bovis infections are significantly higher in TB patients who have had direct contact with livestock or their unpasteurized products. M. bovis’ intrinsic ability to be resistant to some of the anti-TB drugs poses hinderance to treatment and control of mycobacterial lung diseases while increasing drug resistant development.

Dr Asare hypothesises that zoonotic spill over may be the cause of frequent isolation of M. bovis in clinical cases. This proposed research seeks to adopt comprehensive and enhanced sampling from both humans and animals, combined with computational biology analysis, to be able to model and predict future zoonotic spill overs and define clinically relevant mycobacteria, to aid in the effective control and management of mycobacterial lung diseases.

Dr Asare’s placement is at the laboratory of Prof. Julian Parkhill at the Department of Veterinary Medicine, University of Cambridge. The team are experts in zoonotic transmissions especially with regards to bovine tuberculosis transmission and have deep knowledge in mycobacterial infections - making it the perfect place to network. His home organisation currently leads research into mycobacterial diseases in Ghana and are well suited to address the hypothesis posed after gaining in-depth capacity in computational biology and modelling from his placement period.

“In-depth knowledge and capacity in computational biology will aid tracking of zoonotic spill overs to control and possibly prevent future mycobacterial lung diseases.”