Dr Haddy Fye



Dr Haddy Fye at the MRC Research Unit, The Gambia
Proteomics and Expression Pathways of Sickle Cell Anaemia

Dr Haddy FyeAfter completing my DPhil at the University of Oxford in 2013, I opted to return home to the Gambia as an early career research scientist. I joined the PROLIFICA team with a keen desire to gain experience and offer my expertise on the first chronic liver disease study in Sub-Saharan Africa offering treatment to patients infected with the hepatitis B virus.

I currently lead the novel Mass Spectrometry platform at the MRC Gambia Unit; a platform which applies cutting edge scientific methods to the identification of small molecular targets usable as markers of prognosis, diagnosis and outcome in numerous disease models. This role has enabled me to amongst other things, build up my portfolio of research publications in peer-reviewed journals.

It is my intention to use this AREF Research Development Fellowship to apply my experience in metabonomics and proteomics systems biology to the oft-neglected area of sickle cell disease (SCD). This is the most common inherited disorder affecting persons of African descent resulting in significant mortality and morbidity, especially in children.

I have drawn up a proposal which will have me working with well-established research teams in Tanzania, Imperial College London as well as with former colleagues at the University of Oxford. My AREF Fellowship will have me based at the Target Discovery Institute at the University of Oxford where I will I apply emerging technologies to the study of protein expression pathways of SCD.

This pilot work will I hope, provide a strong basis for a more substantive grant application in the future. My ambition is to contribute towards greater awareness of this condition as well as to offer a cost-effective diagnostic method with the potential to be utilized as part of routine pre- natal screening panels.

I look forward to being successful in this venture.